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The PDGFR and epidermal growth factor receptor (EGFR) groups of TK receptors have gained interest as plausible therapy targets for respiratory afflictions, as these receptors have been shown to perform important functions in persistent tissue repair in respiratory fibrosis, bronchitis, and asthma [154]

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For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1 pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Zeng et al., 2016